RNA and cancer /
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| Imprint: | Berlin ; New York : Springer, 2013. |
|---|---|
| Description: | 1 v. : ill. (some col.) ; 24 cm. |
| Language: | English |
| Series: | Cancer treatment and research, 0927-3042 ; v.158 Cancer treatment and research ; v. 158. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/9850167 |
MARC
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| 090 | |a RC268.4 |b .R53 2013 | ||
| 096 | |a QZ 206 | ||
| 245 | 0 | 0 | |a RNA and cancer / |c edited by Jane Wu. |
| 260 | |a Berlin ; |a New York : |b Springer, |c 2013. | ||
| 300 | |a 1 v. : |b ill. (some col.) ; |c 24 cm. | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
| 337 | |a computer |b c |2 rdamedia |0 http://id.loc.gov/vocabulary/mediaTypes/c | ||
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| 490 | 1 | |a Cancer treatment and research, |x 0927-3042 ; |v v.158 | |
| 505 | 0 | 0 | |t Coupling Between Transcription and Alternative Splicing / |r Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt -- |t Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray / |r Marieta Gencheva ... [et al.] -- |t Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing / |r Lulzim Shkreta ... [et al.] -- |t Alternative Splicing of Tumor Suppressors and Oncogenes / |r Claudia Ghigna, Silvano Riva, Giuseppe Biamonti -- |t MicroRNAs in Cancer / |r Jianzhong Jeff Xi -- |t The Perinucleolar Compartment: RNA Metabolism and Cancer / |r John T. Norton, Sui Huang -- |t Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer / |r Christian Kroun Damgaard, Jens Lykke-Andersen -- |t Alternative Pre-mRNA Splicing, Cell Death, and Cancer / |r Kong Ruirui ... [et al.] -- |t Oligonucleotide Therapeutics in Cancer / |r Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani -- |t Clinical Perspective on Chemo-Resistance and the Role of RNA Processing / |r Nancy L. Krett, Shuo Ma, Steven T. Rosen. |
| 588 | |a Description based on print version record. | ||
| 520 | |a In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated aberrant RNAs, new methodology for their detection, and the functional impact on expression of important genes, including oncogenes and tumor suppressor genes. Further topics include the role of microRNAs in cancer and the possible involvement of the perinucleolar compartment. The implications for cancer of regulation of mRNA stability by cellular signaling are discussed, and the importance of splicing defects in the regulation of cell death genes is examined. The potential for the development of oligonucleotide therapeutics is then reviewed before the final chapter considers clinical perspectives on the study of RNA defects in cancer.All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers, leading to improved cancer diagnosis and treatment. | ||
| 650 | 2 | |a Neoplasms |x genetics. | |
| 650 | 2 | |a Neoplasms |x therapy. | |
| 650 | 2 | |a Genetic Therapy. | |
| 650 | 0 | |a Cancer |x Genetic aspects. |0 http://id.loc.gov/authorities/subjects/sh85019509 | |
| 650 | 0 | |a Cancer |x Gene therapy. |0 http://id.loc.gov/authorities/subjects/sh92005201 | |
| 655 | 4 | |a Electronic books. | |
| 650 | 7 | |a Cancer |x Gene therapy. |2 fast |0 http://id.worldcat.org/fast/fst00845367 | |
| 650 | 7 | |a Cancer |x Genetic aspects. |2 fast |0 http://id.worldcat.org/fast/fst00845368 | |
| 700 | 1 | |a Wu, Jane Y. |0 http://id.loc.gov/authorities/names/n2013183822 |1 http://viaf.org/viaf/304886881 | |
| 776 | 0 | 8 | |i Print version: |t RNA and cancer. |d Berlin : Springer, 2013. |z 9783642316586 |
| 830 | 0 | |a Cancer treatment and research ; |v v. 158. |x 0927-3042 | |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/978-3-642-31659-3 |y SpringerLink |
| 903 | |a HeVa | ||
| 035 | |a (ICU)9850167 | ||
| 929 | |a eresource | ||
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| 928 | |t Library of Congress classification |a RC268.4 .R53 2013 |l Online |c UC-FullText |u http://dx.doi.org/10.1007/978-3-642-31659-3 |z SpringerLink |g ebooks |i 11492648 | ||