Targeting the Wnt pathway in cancer /

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Bibliographic Details
Imprint:	New York : Springer, c2011.
Description:	1 online resource (xi, 240 p.) : ill., tabs., figs.
Language:	English
Subject:	Wnt genes. Cancer -- Genetic aspects. Neoplasms -- therapy. Neoplasms -- genetics. Signal Transduction. Targeted Gene Repair -- methods. Wnt Proteins. Cancer -- Genetic aspects. Wnt genes.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/8897299

Hidden Bibliographic Details
Other authors / contributors:	Goss, Kathleen Heppner. Kahn, Michael.
ISBN:	9781441980236 (electronic bk.) 1441980237 (electronic bk.)
Notes:	Includes bibliographical references and index. Description based on print version record.
Summary:	Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of i -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic targe.

Table of Contents:

An Introduction to Wnt Signaling
Regulation of Wnt Secretion and Distribution
Wnt Signaling in Stem Cells
Crosstalk of the Wnt Signaling Pathway
Dysregulation of the Wnt Pathway in Solid Tumors
WNT/β-Catenin Signaling in Leukemia
Use of Genetically Engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Targeting Wnt Signalling in Cancer
Inhibiting the Wnt Signaling Pathway with Small Molecules
Targeting of Wnt Signaling Inside the Nucleus.

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