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110301s2011 nyua ob 001 0 eng d |
| 020 |
|
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|a 9781441980236 (electronic bk.)
|
| 020 |
|
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|a 1441980237 (electronic bk.)
|
| 035 |
|
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|a (OCoLC)704399511
|
| 037 |
|
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|a 978-1-4419-8022-9
|b Springer
|n http://www.springerlink.com
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| 040 |
|
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|a GW5XE
|b eng
|c GW5XE
|d EBLCP
|d VAM
|d OCLCQ
|d MHW
|d OCLCQ
|d N$T
|d COO
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| 049 |
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|a CGUA
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| 072 |
|
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|a HEA
|x 039030
|2 bisacsh
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| 072 |
|
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|a MED
|x 062000
|2 bisacsh
|
| 082 |
0 |
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|a 616.99/4042
|2 22
|
| 090 |
|
|
|a RC268.42
|b .T37 2011
|
| 245 |
0 |
0 |
|a Targeting the Wnt pathway in cancer /
|c Kathleen H. Goss, Michael Kahn, Editors.
|
| 260 |
|
|
|a New York :
|b Springer,
|c c2011.
|
| 300 |
|
|
|a 1 online resource (xi, 240 p.) :
|b ill., tabs., figs.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|0 http://id.loc.gov/vocabulary/contentTypes/txt
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|0 http://id.loc.gov/vocabulary/mediaTypes/c
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
|0 http://id.loc.gov/vocabulary/carriers/cr
|
| 504 |
|
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|a Includes bibliographical references and index.
|
| 520 |
|
|
|a Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of i -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic targe.
|
| 588 |
|
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|a Description based on print version record.
|
| 505 |
0 |
|
|a An Introduction to Wnt Signaling -- Regulation of Wnt Secretion and Distribution -- Wnt Signaling in Stem Cells -- Crosstalk of the Wnt Signaling Pathway -- Dysregulation of the Wnt Pathway in Solid Tumors -- WNT/β-Catenin Signaling in Leukemia -- Use of Genetically Engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer -- Targeting Wnt Signalling in Cancer -- Inhibiting the Wnt Signaling Pathway with Small Molecules -- Targeting of Wnt Signaling Inside the Nucleus.
|
| 650 |
|
0 |
|a Wnt genes.
|0 http://id.loc.gov/authorities/subjects/sh2003001478
|
| 650 |
|
0 |
|a Cancer
|x Genetic aspects.
|0 http://id.loc.gov/authorities/subjects/sh85019509
|
| 650 |
1 |
2 |
|a Neoplasms
|x therapy.
|
| 650 |
2 |
2 |
|a Neoplasms
|x genetics.
|
| 650 |
2 |
2 |
|a Signal Transduction.
|
| 650 |
2 |
2 |
|a Targeted Gene Repair
|x methods.
|
| 650 |
2 |
2 |
|a Wnt Proteins.
|
| 650 |
|
4 |
|a Medicine.
|
| 650 |
|
7 |
|a HEALTH & FITNESS / Diseases / Cancer
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL / Oncology
|2 bisacsh
|
| 655 |
|
4 |
|a Electronic books.
|
| 650 |
|
7 |
|a Cancer
|x Genetic aspects.
|2 fast
|0 http://id.worldcat.org/fast/fst00845368
|
| 650 |
|
7 |
|a Wnt genes.
|2 fast
|0 http://id.worldcat.org/fast/fst01176457
|
| 700 |
1 |
|
|a Goss, Kathleen Heppner.
|0 http://id.loc.gov/authorities/names/no98130832
|1 http://viaf.org/viaf/66097697
|
| 700 |
1 |
|
|a Kahn, Michael.
|0 http://id.loc.gov/authorities/names/n89200763
|1 http://viaf.org/viaf/56699095
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-1-4419-8023-6
|y SpringerLink
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|
|t Library of Congress classification
|a RC268.42 .T37 2011
|l Online
|c UC-FullText
|u http://dx.doi.org/10.1007/978-1-4419-8023-6
|z SpringerLink
|g ebooks
|i 11482771
|
