Targeting the Wnt pathway in cancer /

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Bibliographic Details
Imprint:New York : Springer, c2011.
Description:1 online resource (xi, 240 p.) : ill., tabs., figs.
Subject:Wnt genes.
Cancer -- Genetic aspects.
Neoplasms -- therapy.
Neoplasms -- genetics.
Signal Transduction.
Targeted Gene Repair -- methods.
Wnt Proteins.
HEALTH & FITNESS / Diseases / Cancer
MEDICAL / Oncology
Cancer -- Genetic aspects.
Wnt genes.
Electronic books.
Format: E-Resource Book
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Hidden Bibliographic Details
Other authors / contributors:Goss, Kathleen Heppner.
Kahn, Michael.
ISBN:9781441980236 (electronic bk.)
1441980237 (electronic bk.)
Notes:Includes bibliographical references and index.
Description based on print version record.
Summary:Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of i -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic targe.