Gene therapy for cancer /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, c2007.
Description:1 online resource (xi, 469 p.) : ill. (some col.)
Series:Cancer drug discovery and development
Cancer drug discovery and development.
Subject:Cancer -- Gene therapy.
Neoplasms -- genetics.
Neoplasms -- therapy.
Gene Therapy -- methods.
Cancer -- Gene therapy.
Electronic books.
Format: E-Resource Book
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Other authors / contributors:Hunt, Kelly K.
Vorburger, Stephan A.
Swisher, Stephen G.
1588294722 (alk. paper)
9781588294722 (alk. paper)
Notes:Includes bibliographical references and index.
Description based on print version record.
Other form:Print version: Gene therapy for cancer. Totowa, N.J. : Humana Press, c2007 1588294722 9781588294722
Table of Contents:
  • Preface
  • Contributors
  • I. Vectors
  • 1. Adenovector-Mediated Cancer Gene Therapy
  • 2. Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors
  • 3. Lentiviral and Retroviral Vector Systems
  • 4. Vaccinia and Pox-Virus
  • 5. Herpes Simplex Virus as a Therapy for Cancer
  • 6. Alphavirus Vectors for Gene Therapy Applications
  • 7. Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors
  • 8. Parvovirus Vectors
  • 9. Nonviral Vector Systems
  • II. Gene Therapy Approaches
  • 10. Oncogenes, Tumor Suppressor Genes, and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy
  • 11. Gene Silencing Therapy Against Cancer
  • 12. Tumor Targeting-Retargeted Adenovirus
  • 13. Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials
  • 14. Cytokine Gene Therapy for Genitourinary Cancer
  • 15. Combination of Gene Therapy with Radiation
  • 16. Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells
  • 17. Nonviral Genetic Vaccines for Cancer
  • 18. Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment
  • 19. Tumor-Specific Replicating Adenoviruses: [Delta] 24 for Human Gliomas
  • III. Clinical Applications
  • 20. Problems, Side Effects, and Disappointments in Clinical Cancer Gene Therapy
  • 21. Trials and Tribulations in Developing Clinical Trials of Gene Therapy: E1A for Breast or Ovarian Cancer
  • 22. Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus
  • 23. MDA-7/IL-24 as a Multi-Modality Therapy for Cancer
  • 24. Development of Therapeutic Genes for Breast Cancer Treatment
  • 25. Steps in a Translational Cancer Gene Therapy Trial
  • Index