Actin-monomer-binding proteins /
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| Imprint: | Austin, Tex. : Landes Bioscience ; New York, N.Y. : Springer, c2007. |
|---|---|
| Description: | 1 online resource (118 p.) : ill. (some col.) |
| Language: | English |
| Series: | Molecular biology intelligence unit Molecular biology intelligence unit (Unnumbered) |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/8884130 |
Table of Contents:
- Preface
- 1. How Actin Assembly Is Modulated at Filament Barbed Ends in Motile Processes
- Proteins That Control Barbed End Assembly by Interacting Specifically with Actin Filament Barbed Ends
- Proteins That Control Barbed End Assembly by Acting on Pointed End Disassembly: ADF/Cofilin
- Proteins That Control Filament Assembly by Interacting with G-Actin
- 2. Proteins of the Actin Depolymerizing Factor/Cofilin Family
- Overview of the ADF/Cofilin Family
- Structure and Function of ADF/Cofilin
- Regulation of ADF/Cofilin Activity
- Role of ADF/Cofilin Proteins in Cell Biology and Development
- 3. Profilin, an Essential Control Element for Actin Polymerization
- Profilin and Profilin: Actin
- Isoform Diversity
- The Profilin Structure
- Poly-(L-Proline) and Profilin
- Structure of Profilin: Actin and Its Role in Filament Formation
- Polyphosphoinositides and Profilin
- Profilin in Cell Motility
- Profilin in the Nucleus
- Profilin in the Brain
- 4. Srv2/Cyclase-Associated Protein (CAP): A Multi-Functional Recycling Center for Actin Monomers and Cofilin
- CAP Atomic Structure and Assembly into Complexes
- Biochemical Properties of the CAP-Actin Association
- CAP Mechanism and Cellular Function
- In Vivo Regulation of CAP
- 5. Twinfilin Family of Actin Monomer-Binding Proteins
- Structural Features of Twinfilin
- Biochemical Properties and Interaction Partners of Twinfilin
- Phenotypes and Cell Biological Functions
- Regulation of Twinfilin's Activity
- The Role of Twinfilin in Actin Dynamics
- 6. Intracellular [Beta]-Thymosins
- Amino Acid Sequences and Phylogenetic Distribution of [Beta]-Thymosins
- Cell and Tissue Distribution
- Structure of [Beta]-Thymosins
- Intracellular Distribution of Thymosin [Beta]4
- [Beta]-Thymosin/WH2 Domain
- Sequestering of G-Actin by [Beta]-Thymosins
- Structure of the G-Actin-Thymosin [Beta]4 Complex
- Extracellular [Beta]-Thymosins
- Apoptosis and [Beta]-Thymosins
- Quantitative Determination and Expression of [Beta]-Thymosins
- Isolation of [Beta]-Thymosins
- Outstanding Questions
- 7. Multirepeat [Beta]-Thymosins
- The Multirepeat [Beta]-Thymosin Family: Evolutionary Relationships and Structural Characteristics
- Biochemical Studies Reveal Functional Versatility within the [Beta]-Thymosin Repeats in Affecting Actin Dynamics
- Multirepeat [Beta]-Thymosins Are Essential in Neuronal Development and Plasticity and/or in Reproduction
- 8. Wasp and Wave Family Proteins
- Promoting Branched Elongation of Actin Filaments through the Arp2/3 Complex
- Structural Features of Wasp and N-Wasp and Wave Proteins
- N-Wasp Mediated Actin Polymerization Events
- Wave-Complexes Acts as Signaling Machineries in Cellular Protrusions
- 9. The Verprolins as Regulators of Actin Dynamics
- The Verprolins Have Multiple Binding Partners
- Genetic Links to Actin Regulation
- The Vertebrate Verprolins as Actin Binding Proteins
- Verprolin and the Wasp Family of Proteins
- Verprolin and the Wiskott-Aldrich Syndrome
- 10. A Common Binding Site for Actin-Binding Proteins on the Actin Surface
- A Prevalent Target-Binding Cleft in Actin
- Conformational Plasticity of the Target-Binding Cleft in Actin
- Crosstalk between the Target-Binding and Nucleotide Clefts
- Implication for Other Actin-Binding Proteins
- Index