Total synthesis of bioactive natural products by palladium-catalyzed domino cyclization of allenes and related compounds /

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Bibliographic Details
Author / Creator:Inuki, Shinsuke.
Imprint:Tokyo ; New York : Springer, c2012.
Description:1 online resource (xvi, 106 p.) : ill.
Language:English
Series:Springer theses
Springer theses.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/8872052
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ISBN:9784431540434 (electronic bk.)
4431540431 (electronic bk.)
9784431540427
Notes:Originally presented as author's thesis (Ph. D.)--Kyoto University.
Includes bibliographical references.
Summary:The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26 per cent overall yield in seven steps), lysergic acid (4.0 per cent overall yield in fifteen steps), lysergol (3.6 per cent overall yield in fifteen steps) and isolysergol (8.2 per cent overall yield in eleven steps) have been achieved. These are