Suicide gene therapy : methods and reviews /
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| Imprint: | Totowa, N.J. : Humana Press, c2004. |
|---|---|
| Description: | xiv, 555 p. : ill. (some col.) ; 24 cm. |
| Language: | English |
| Series: | Methods in molecular medicine, 1543-1894 ; 90 |
| Subject: | |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/5040178 |
Table of Contents:
- Preface
- Contributors
- 1. Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy
- 2. Introduction to Vectors for Suicide Gene Therapy
- 3. Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans
- 4. Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors
- 5. Replication-Selective Oncolytic Adenoviruses
- 6. Retroviral Vectors for Suicide Gene Therapy
- 7. Nonviral Liposomes
- 8. Peptide- and Polymer-Based Gene Delivery Vehicles
- 9. Design of Prodrugs for Suicide Gene Therapy
- 10. Cytochrome P450-Based Gene Therapies for Cancer
- 11. Tumor Sensitization to Purine Analogs by E. coli PNP
- 12. Enzyme-Prodrug Systems: Carboxylesterase/CPT-11
- 13. Enzyme-Prodrug Systems: Thymidine Phosphorylase/5'-Deoxy-5-Fluorouridine
- 14. Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments
- 15. Extracellular [beta]-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy
- 16. Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis
- 17. Combination Suicide Gene Therapy
- 18. Immune Response to Suicide Gene Therapy
- 19. Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus
- 20. Radiation-Activated Antitumor Vectors
- 21. In Vitro and In Vivo Models for the Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors
- 22. Suicide Gene Therapy in Liver Tumors
- 23. Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine
- 24. The Nitroreductase/CB1954 Enzyme-Prodrug System
- 25. Side Effects of Suicide Gene Therapy
- 26. Antibody-Directed Enzyme-Prodrug Therapy
- 27. Bioreductive Prodrugs for Cancer Therapy
- Index
