Gene therapy of cancer : methods and protocols /
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| Imprint: | Totowa, N.J. : Humana Press, c2000. |
|---|---|
| Description: | xvi, 645 p. : ill. ; 24 cm. |
| Language: | English |
| Series: | Methods in molecular medicine 35 |
| Subject: | Cancer -- Gene therapy -- Laboratory manuals. Neoplasms -- therapy. Gene Therapy -- methods. Cancer -- Gene therapy. Laboratory manuals. |
| Format: | Print Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/4221529 |
Table of Contents:
- Preface
- Contributors
- Part I.. Experimental Approaces in Cancer Gene Therapy
- A. Immunotherapy/Tumor Vaccination
- 1. Immunizing Potential of Cytokine-Transduced Tumor Cells
- 2. Particle-Mediated Gene Transfer into Dendritic Cells: A Novel Strategy for the Induction of Immune Responses against Tumor Antigens
- 3. Cancer Gene Therapy with Heat Shock Protein-65 Gene
- 4. Recombinant Vaccinia Virus MVA for Generation and Analysis of T Cell Responses Against Tumor Associated Antigens
- B. Suicide Gene Therapy
- 5. Selection of Cytochrome P450 Genes for Use in Prodrug Activation-Based Cancer Gene Therapy
- 6. Construction of P450-Expressing Tumor Cell Lines Using Retroviruses
- 7. In Vitro Methods for Evaluation of P450-Based Anticancer Gene Therapy
- 8. Tumor Models for Evaluation of P450 Gene Therapy In Vivo
- C. Anti-Oncogene and Suppressor Gene Therapy
- 9. Intracellular Single-Chain Antibodies for Gene Therapy
- 10. Combined Adenoviral Transfer of Tumor Suppressor and Cell-Cycle Genes for Tumor-Cell Appoptosis
- D. Antisense Gene Therapy
- 11. Inhibition of Cell Growth by Antisense Oligonucleotides Targeting the Growth-Related Protein Kinase c-raf
- 12. IGF-1 Antisense Strategies for Cancer Treatment
- E. Ribozyme Gene Therapy
- 13. Anti-MDR1 Ribozyme Gene Therapy
- 14. Anti-c-erbB2 Ribozyme for Gene Therapy of Breast Cancer
- 15. Anti-K-ras Ribozyme Adenoviral Vector for Gene Therapy of Non-Small Cell Lung Cancer
- F. Delivery Systems and Tumor Targeting
- 16. Green Fluorescent Protein Retroviral Vector: Generation of High-Titer Producer Cells and Virus Supernatant
- 17. HSV-1 Vectors for Gene Therapy of Experimental CNS Tumors
- 18. Intratumoral Injection of Naked DNA
- 19. Cationic Liposome Gene Transfer
- 20. In Vivo Particle-Mediated Gene Transfer for Cancer Therapy
- 21. Gene Targeting to Hepatomas (AFP)
- 22. Adenovirus-Mediated Targeted Gene Therapy for Breast Cancer and for Purging Hematopoietic Stem-Cell Sources
- 23. Chemotherapy-Inducible Vector for Gene Therapy of Cancer
- G. Alternative Approaches in Cancer Gene Therapy
- 24. Oncolytic Adenoviral Vectors
- 25. Genetically Modified Clostridium for Gene Therapy of Tumors
- 26. Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene
- Part II.. Clinical Protocols for Cancer Gene Therapy
- A. Immunotherapy/Tumor Vaccination
- 27. Ex Vivo Cytokine Gene Transfer in Melanomas by Using Particle Bombardment
- 28. Intratumoral Gene Transfer of the HLA-B7 Gene Into Colon Carcinoma Metastases
- 29. Hybrid Cell Vaccination in Patients With Metastatic Melanoma
- B. Suicide Gene Therapy
- 30. Retroviral Transfer of the Herpes Simplex Virus-Thymidine Kinase (HSV-tK) Gene for the Treatment of Cancer
- 31. Gene Therapy for Treatment of Brain Tumors (HSV-tK In Vivo Gene Transfer): A Case Study
- 32. Gene Therapy of Glioblastoma Multiforme with a Bicistronic Retroviral Vector Expressing Human IL-2 and HSV-tK
- 33. Intratumoral Gene Transfer of the Cytosine Deaminase Gene for the Treatment of Breast Cancer
- C. Anti-Oncogene and Suppressor Gene Therapy
- 34. Adenovirus-Mediated Wild-Type p53 Gene Transfer into Head and Neck Cancers
- 35. Direct DNA Injection (p53) into HCC Tumors
- 36. A Phase II Trial of Intratumoral Injection with a Selectively Replicating Adenovirus (ONYX-015) in Patients with Recurrent, Refractory Squamous Cell Carcinoma of the Head and Neck
- D. Antisense Gene Therapy
- 37. c-myb Antisense Oligonucleotide Therapeutics for Hematologic Malignancies
- 38. Ovarian Cancer Gene Therapy with BRCA1--An Overview
- 39. Methods for Chemoprotection and Chemosensitization: MDR-1 For Chemoprotection Using Retroviruses to Modify Hematopoietic Cells and Cytosine Deaminase for Chemosensitization Using Adenoviral Vectors to Modify Epithelian Neoplastic Cells
- Index
