Gene therapy of cancer : methods and protocols /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, c2000.
Description:xvi, 645 p. : ill. ; 24 cm.
Series:Methods in molecular medicine 35
Subject:Cancer -- Gene therapy -- Laboratory manuals.
Neoplasms -- therapy.
Gene Therapy -- methods.
Cancer -- Gene therapy.
Laboratory manuals.
Format: Print Book
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Other authors / contributors:Walther, Wolfgang.
Stein, Ulrike.
ISBN:0896037142 (hard : alk. paper)
0896038432 (comb : alk. paper)
Notes:Includes bibliographical references and index.
Table of Contents:
  • Preface
  • Contributors
  • Part I.. Experimental Approaces in Cancer Gene Therapy
  • A. Immunotherapy/Tumor Vaccination
  • 1. Immunizing Potential of Cytokine-Transduced Tumor Cells
  • 2. Particle-Mediated Gene Transfer into Dendritic Cells: A Novel Strategy for the Induction of Immune Responses against Tumor Antigens
  • 3. Cancer Gene Therapy with Heat Shock Protein-65 Gene
  • 4. Recombinant Vaccinia Virus MVA for Generation and Analysis of T Cell Responses Against Tumor Associated Antigens
  • B. Suicide Gene Therapy
  • 5. Selection of Cytochrome P450 Genes for Use in Prodrug Activation-Based Cancer Gene Therapy
  • 6. Construction of P450-Expressing Tumor Cell Lines Using Retroviruses
  • 7. In Vitro Methods for Evaluation of P450-Based Anticancer Gene Therapy
  • 8. Tumor Models for Evaluation of P450 Gene Therapy In Vivo
  • C. Anti-Oncogene and Suppressor Gene Therapy
  • 9. Intracellular Single-Chain Antibodies for Gene Therapy
  • 10. Combined Adenoviral Transfer of Tumor Suppressor and Cell-Cycle Genes for Tumor-Cell Appoptosis
  • D. Antisense Gene Therapy
  • 11. Inhibition of Cell Growth by Antisense Oligonucleotides Targeting the Growth-Related Protein Kinase c-raf
  • 12. IGF-1 Antisense Strategies for Cancer Treatment
  • E. Ribozyme Gene Therapy
  • 13. Anti-MDR1 Ribozyme Gene Therapy
  • 14. Anti-c-erbB2 Ribozyme for Gene Therapy of Breast Cancer
  • 15. Anti-K-ras Ribozyme Adenoviral Vector for Gene Therapy of Non-Small Cell Lung Cancer
  • F. Delivery Systems and Tumor Targeting
  • 16. Green Fluorescent Protein Retroviral Vector: Generation of High-Titer Producer Cells and Virus Supernatant
  • 17. HSV-1 Vectors for Gene Therapy of Experimental CNS Tumors
  • 18. Intratumoral Injection of Naked DNA
  • 19. Cationic Liposome Gene Transfer
  • 20. In Vivo Particle-Mediated Gene Transfer for Cancer Therapy
  • 21. Gene Targeting to Hepatomas (AFP)
  • 22. Adenovirus-Mediated Targeted Gene Therapy for Breast Cancer and for Purging Hematopoietic Stem-Cell Sources
  • 23. Chemotherapy-Inducible Vector for Gene Therapy of Cancer
  • G. Alternative Approaches in Cancer Gene Therapy
  • 24. Oncolytic Adenoviral Vectors
  • 25. Genetically Modified Clostridium for Gene Therapy of Tumors
  • 26. Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene
  • Part II.. Clinical Protocols for Cancer Gene Therapy
  • A. Immunotherapy/Tumor Vaccination
  • 27. Ex Vivo Cytokine Gene Transfer in Melanomas by Using Particle Bombardment
  • 28. Intratumoral Gene Transfer of the HLA-B7 Gene Into Colon Carcinoma Metastases
  • 29. Hybrid Cell Vaccination in Patients With Metastatic Melanoma
  • B. Suicide Gene Therapy
  • 30. Retroviral Transfer of the Herpes Simplex Virus-Thymidine Kinase (HSV-tK) Gene for the Treatment of Cancer
  • 31. Gene Therapy for Treatment of Brain Tumors (HSV-tK In Vivo Gene Transfer): A Case Study
  • 32. Gene Therapy of Glioblastoma Multiforme with a Bicistronic Retroviral Vector Expressing Human IL-2 and HSV-tK
  • 33. Intratumoral Gene Transfer of the Cytosine Deaminase Gene for the Treatment of Breast Cancer
  • C. Anti-Oncogene and Suppressor Gene Therapy
  • 34. Adenovirus-Mediated Wild-Type p53 Gene Transfer into Head and Neck Cancers
  • 35. Direct DNA Injection (p53) into HCC Tumors
  • 36. A Phase II Trial of Intratumoral Injection with a Selectively Replicating Adenovirus (ONYX-015) in Patients with Recurrent, Refractory Squamous Cell Carcinoma of the Head and Neck
  • D. Antisense Gene Therapy
  • 37. c-myb Antisense Oligonucleotide Therapeutics for Hematologic Malignancies
  • 38. Ovarian Cancer Gene Therapy with BRCA1--An Overview
  • 39. Methods for Chemoprotection and Chemosensitization: MDR-1 For Chemoprotection Using Retroviruses to Modify Hematopoietic Cells and Cytosine Deaminase for Chemosensitization Using Adenoviral Vectors to Modify Epithelian Neoplastic Cells
  • Index