From neuron to brain : a cellular and molecular approach to the function of the nervous system.
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Author / Creator: | Nicholls, John G. |
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Edition: | 3rd ed. / John G. Nicholls, A. Robert Martin, Bruce G. Wallace. |
Imprint: | Sunderland, Mass. : Sinauer Associates, ©1992. |
Description: | xx, 807 pages : illustrations (some color), portrait ; 24 cm |
Language: | English |
Subject: | Neurophysiology. Brain. Neurons. Nervous System Physiological Phenomena. Brain. Neurons. Neurophysiology. |
Format: | Print Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/1711050 |
Table of Contents:
- Part 1. Introduction
- Chapter 1.. Principles of Signaling and Organization
- Signaling in Simple Neuronal Circuits
- Organization of the Retina
- Signaling in Nerve Cells
- Cellular and Molecular Biology of Neurons
- Signals for Development of the Nervous System
- Regeneration of the Nervous System after Injury
- Part 2. Signaling in the Nervous System
- Chapter 2.. Ion Channels and Signaling
- Properties of Ion Channels
- Measurement of Single-Channel Currents
- Box 2.1. Measuring Channel Conductance
- Chapter 3.. Structure of Ion Channels
- The Nicotinic Acetylcholine Receptor
- A Receptor Superfamily
- Voltage-Activated Channels
- Other Channels
- Diversity of Subunits
- Conclusion
- Box 3.1. Cloning Receptors and Channels
- Box 3.2. Classification of Amino Acids
- Box 3.3. Expression of Receptors and Channels in Xenopus Oocytes
- Chapter 4.. Transport Across Cell Membranes
- The Sodium-Potassium Exchange Pump
- Calcium Pumps
- Sodium-Calcium Exchange
- Chloride Transport
- Transport of Neurotransmitters
- Molecular Structure of Transporters
- Significance of Transport Mechanisms
- Chapter 5.. Ionic Basis of the Resting Potential
- A Model Cell
- Membrane Potentials in Squid Axons
- Changes in Membrane Potential
- Chapter 6.. Ionic Basis of the Action Potential
- Sodium and Potassium Currents
- Voltage Clamp Experiments
- Gating Currents
- The Role of Calcium in Excitation
- Box 6.1. The Voltage Clamp
- Chapter 7.. Neurons as Conductors of Electricity
- Passive Electrical Properties of Nerve and Muscle Membranes
- Propagation of Action Potentials
- Conduction in Dendrites
- Pathways for Current Flow between Cells
- Box 7.1. Electrotonic Potentials and the Membrane Time Constant
- Box 7.2. Classification of Nerve Fibers in Vertebrates
- Box 7.3. Stimulating and Recording with External Electrodes
- Box 7.4. Current Flow between Cells
- Chapter 8.. Properties and Functions of Neuroglial Cells
- Physiological Properties of Neuroglial Cell Membranes
- Functions of Neuroglial Cells
- Effects of Neuronal Activity on Glial Cells
- Glial Cells and the Blood-Brain Barrier
- Glial Cells and Immune Responses of the CNS
- Box 8.1. The Blood-Brain Barrier
- Chapter 9.. Principles of Direct Synaptic Transmission
- Nerve Cells and Synaptic Connections
- Electrical Synaptic Transmission
- Chemical Synaptic Transmission
- Box 9.1. Electrical Model of the Motor End Plate
- Direct Synaptic Inhibition
- Chapter 10.. Indirect Mechanisms of Synaptic Transmission
- Metabotropic Receptors and G Proteins
- Direct Modulation of Channel Function by G Proteins
- G Protein Activation of Cytoplasmic Second Messenger Systems
- Calcium as an Intracellular Second Messenger
- Prolonged Time Course of Indirect Transmitter Action
- Box 10.1. Identifying Responses Mediated by G Proteins
- Box 10.2. Cyclic AMP as a Second Messenger
- Box 10.3. Diacylglycerol and IP[subscript 3] as Second Messengers
- Box 10.4. Formation and Metabolism of Arachidonic Acid
- Chapter 11.. Transmitter Release
- Characteristics of Transmitter Release
- Quantal Release
- Vesicle Hypothesis of Transmitter Release
- Chapter 12.. Synaptic Plasticity
- Short-Term Changes in Signaling
- Long-Term Changes in Signaling
- Chapter 13.. Cellular and Molecular Biochemistry of Synaptic Transmission
- Neurotransmitters
- Neurotransmitter Synthesis
- Storage of Transmitters in Synaptic Vesicles
- Axonal Transport
- Transmitter Release and Vesicle Recycling
- Transmitter Receptor Localization
- Removal of Transmitters from the Synaptic Cleft
- Box 13.1. The SNARE Hypothesis
- Chapter 14.. Neurotransmitters in the Central Nervous System
- Mapping Transmitter Distribution
- Peptide Transmitters in the CNS
- Regulation of Central Nervous System Function by Biogenic Amines
- Box 14.1. Molecular Methods and CNS transmitters
- Part 3. Integrative Mechanisms
- Chapter 15.. Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees
- From Neurons to Behavior and Vice Versa
- Navigation by Ants and Bees
- Why Should One Work on Invertebrate Nervous Systems?
- Chapter 16.. Autonomic Nervous System
- Functions under Involuntary Control
- Synaptic Transmission by Postganglionic Axons
- Box 16.1. The Path to Understanding Sympathetic Mechanisms
- Chapter 17.. Transduction of Mechanical and Chemical Stimuli
- Stimulus Coding by Mechanoreceptors
- Transduction of Mechanical Stimuli
- Olfaction
- Mechanisms of Taste (Gustation)
- Transduction of Nociceptive and Thermal Stimuli
- Box 17.1. Sensory Epithelia of the Inner Ear
- Chapter 18.. Processing of Somatosensory and Auditory Signals
- The Somatosensory System: Tactile Recognition
- The Auditory System: Encoding Sound Frequency
- Box 18.1. Brodmann's Areas
- Chapter 19.. Transduction and Signaling in the Retina
- The Eye
- The Retina
- Visual Pigments
- Transduction by Photoreceptors
- Transmission from Photoreceptors to Bipolar Cells
- Receptive Fields of Ganglion Cells
- Box 19.1. Adaptation of Photoreceptors
- Chapter 20.. Signaling in the Lateral Geniculate Nucleus and the Primary Visual Cortex
- The Lateral Geniculate Nucleus
- Cytoarchitecture of the Cortex
- Strategies for Exploring the Cortex
- Chapter 21.. Functional Architecture of the Visual Cortex
- Ocular Dominance Slabs and Orientation Columns
- Parallel Processing of Form, Motion, and Color
- The Integration of Visual Information
- Where Do We Go from Here?
- Box 21.1. Color Constancy
- Box 21.2. Corpus Callosum
- Chapter 22.. Cellular Mechanisms of Motor Control
- The Motor Unit
- Spinal Reflexes
- Generation of Coordinated Movement
- The Organization of Motor Pathways
- Motor Cortex and the Execution of Voluntary Movement
- The Cerebellum
- The Basal Ganglia
- Box 22.1. Extracellular Recording of Motor Activity
- Part 4. Development of the Nervous System
- Chapter 23.. Development of the Nervous System
- Early Neural Morphogenesis
- Regional Specification of Neural Tissue
- Determination of Neuronal and Glial Cell Identity
- Axon Outgrowth
- Axon Guidance
- Target Innervation
- Synapse Formation
- Growth Factors and Survival of Neurons
- Competitive Interactions during Development
- General Considerations of Neural Specificity
- Box 23.1. Discovery of Nerve Growth Factor
- Chapter 24.. Denervation and Regeneration of Synaptic Connections
- Changes in Axotomized Neurons and the Surrounding Glial Cells
- Effects of Denervation on Postsynaptic Cells
- Regeneration in the Vertebrate Peripheral Nervous System
- Role of Basal Lamina at Regenerating Neuromuscular Synapses
- Regeneration in the Mammalian CNS
- Chapter 25.. Critical Periods in Visual and Auditory Systems
- The Visual System in Newly Born Monkeys and Kittens
- Effects of Abnormal Experience in Early Life
- Requirements for Maintenance of Functioning Connections in the Visual System
- Cellular and Molecular Mechanisms of Deprivation Changes
- Critical Periods in the Auditory System
- Critical Periods for Higher Functions
- Part 5. Conclusion
- Chapter 26.. Open Questions
- Appendix A.. Current Flow in Electrical Circuits
- Appendix B.. Metabolic Pathways for the Synthesis and Inactivation of Low-Molecular-Weight Transmitters
- Appendix C.. Structures and Pathways of the Brain
- Glossary
- Bibliography
- Index