From neuron to brain : a cellular and molecular approach to the function of the nervous system.

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Bibliographic Details
Author / Creator:Nicholls, John G.
Edition:3rd ed. / John G. Nicholls, A. Robert Martin, Bruce G. Wallace.
Imprint:Sunderland, Mass. : Sinauer Associates, ©1992.
Description:xx, 807 pages : illustrations (some color), portrait ; 24 cm
Language:English
Subject:Neurophysiology.
Brain.
Neurons.
Nervous System Physiological Phenomena.
Brain.
Neurons.
Neurophysiology.
Format: Print Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/1711050
Hidden Bibliographic Details
Other uniform titles:Martin, A. Robert, 1928-
Wallace, Bruce G., 1947-
Kuffler, Stephen W. From neuron to brain.
ISBN:0878935800
9780878935802
Notes:Revised edition of: From neuron to brain / Stephen W. Kuffler, John G. Nicholls, A. Robert Martin. 2nd ed. c1984.
Includes bibliographical references (pages 729-777) and index.
Table of Contents:
  • Part 1. Introduction
  • Chapter 1.. Principles of Signaling and Organization
  • Signaling in Simple Neuronal Circuits
  • Organization of the Retina
  • Signaling in Nerve Cells
  • Cellular and Molecular Biology of Neurons
  • Signals for Development of the Nervous System
  • Regeneration of the Nervous System after Injury
  • Part 2. Signaling in the Nervous System
  • Chapter 2.. Ion Channels and Signaling
  • Properties of Ion Channels
  • Measurement of Single-Channel Currents
  • Box 2.1. Measuring Channel Conductance
  • Chapter 3.. Structure of Ion Channels
  • The Nicotinic Acetylcholine Receptor
  • A Receptor Superfamily
  • Voltage-Activated Channels
  • Other Channels
  • Diversity of Subunits
  • Conclusion
  • Box 3.1. Cloning Receptors and Channels
  • Box 3.2. Classification of Amino Acids
  • Box 3.3. Expression of Receptors and Channels in Xenopus Oocytes
  • Chapter 4.. Transport Across Cell Membranes
  • The Sodium-Potassium Exchange Pump
  • Calcium Pumps
  • Sodium-Calcium Exchange
  • Chloride Transport
  • Transport of Neurotransmitters
  • Molecular Structure of Transporters
  • Significance of Transport Mechanisms
  • Chapter 5.. Ionic Basis of the Resting Potential
  • A Model Cell
  • Membrane Potentials in Squid Axons
  • Changes in Membrane Potential
  • Chapter 6.. Ionic Basis of the Action Potential
  • Sodium and Potassium Currents
  • Voltage Clamp Experiments
  • Gating Currents
  • The Role of Calcium in Excitation
  • Box 6.1. The Voltage Clamp
  • Chapter 7.. Neurons as Conductors of Electricity
  • Passive Electrical Properties of Nerve and Muscle Membranes
  • Propagation of Action Potentials
  • Conduction in Dendrites
  • Pathways for Current Flow between Cells
  • Box 7.1. Electrotonic Potentials and the Membrane Time Constant
  • Box 7.2. Classification of Nerve Fibers in Vertebrates
  • Box 7.3. Stimulating and Recording with External Electrodes
  • Box 7.4. Current Flow between Cells
  • Chapter 8.. Properties and Functions of Neuroglial Cells
  • Physiological Properties of Neuroglial Cell Membranes
  • Functions of Neuroglial Cells
  • Effects of Neuronal Activity on Glial Cells
  • Glial Cells and the Blood-Brain Barrier
  • Glial Cells and Immune Responses of the CNS
  • Box 8.1. The Blood-Brain Barrier
  • Chapter 9.. Principles of Direct Synaptic Transmission
  • Nerve Cells and Synaptic Connections
  • Electrical Synaptic Transmission
  • Chemical Synaptic Transmission
  • Box 9.1. Electrical Model of the Motor End Plate
  • Direct Synaptic Inhibition
  • Chapter 10.. Indirect Mechanisms of Synaptic Transmission
  • Metabotropic Receptors and G Proteins
  • Direct Modulation of Channel Function by G Proteins
  • G Protein Activation of Cytoplasmic Second Messenger Systems
  • Calcium as an Intracellular Second Messenger
  • Prolonged Time Course of Indirect Transmitter Action
  • Box 10.1. Identifying Responses Mediated by G Proteins
  • Box 10.2. Cyclic AMP as a Second Messenger
  • Box 10.3. Diacylglycerol and IP[subscript 3] as Second Messengers
  • Box 10.4. Formation and Metabolism of Arachidonic Acid
  • Chapter 11.. Transmitter Release
  • Characteristics of Transmitter Release
  • Quantal Release
  • Vesicle Hypothesis of Transmitter Release
  • Chapter 12.. Synaptic Plasticity
  • Short-Term Changes in Signaling
  • Long-Term Changes in Signaling
  • Chapter 13.. Cellular and Molecular Biochemistry of Synaptic Transmission
  • Neurotransmitters
  • Neurotransmitter Synthesis
  • Storage of Transmitters in Synaptic Vesicles
  • Axonal Transport
  • Transmitter Release and Vesicle Recycling
  • Transmitter Receptor Localization
  • Removal of Transmitters from the Synaptic Cleft
  • Box 13.1. The SNARE Hypothesis
  • Chapter 14.. Neurotransmitters in the Central Nervous System
  • Mapping Transmitter Distribution
  • Peptide Transmitters in the CNS
  • Regulation of Central Nervous System Function by Biogenic Amines
  • Box 14.1. Molecular Methods and CNS transmitters
  • Part 3. Integrative Mechanisms
  • Chapter 15.. Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees
  • From Neurons to Behavior and Vice Versa
  • Navigation by Ants and Bees
  • Why Should One Work on Invertebrate Nervous Systems?
  • Chapter 16.. Autonomic Nervous System
  • Functions under Involuntary Control
  • Synaptic Transmission by Postganglionic Axons
  • Box 16.1. The Path to Understanding Sympathetic Mechanisms
  • Chapter 17.. Transduction of Mechanical and Chemical Stimuli
  • Stimulus Coding by Mechanoreceptors
  • Transduction of Mechanical Stimuli
  • Olfaction
  • Mechanisms of Taste (Gustation)
  • Transduction of Nociceptive and Thermal Stimuli
  • Box 17.1. Sensory Epithelia of the Inner Ear
  • Chapter 18.. Processing of Somatosensory and Auditory Signals
  • The Somatosensory System: Tactile Recognition
  • The Auditory System: Encoding Sound Frequency
  • Box 18.1. Brodmann's Areas
  • Chapter 19.. Transduction and Signaling in the Retina
  • The Eye
  • The Retina
  • Visual Pigments
  • Transduction by Photoreceptors
  • Transmission from Photoreceptors to Bipolar Cells
  • Receptive Fields of Ganglion Cells
  • Box 19.1. Adaptation of Photoreceptors
  • Chapter 20.. Signaling in the Lateral Geniculate Nucleus and the Primary Visual Cortex
  • The Lateral Geniculate Nucleus
  • Cytoarchitecture of the Cortex
  • Strategies for Exploring the Cortex
  • Chapter 21.. Functional Architecture of the Visual Cortex
  • Ocular Dominance Slabs and Orientation Columns
  • Parallel Processing of Form, Motion, and Color
  • The Integration of Visual Information
  • Where Do We Go from Here?
  • Box 21.1. Color Constancy
  • Box 21.2. Corpus Callosum
  • Chapter 22.. Cellular Mechanisms of Motor Control
  • The Motor Unit
  • Spinal Reflexes
  • Generation of Coordinated Movement
  • The Organization of Motor Pathways
  • Motor Cortex and the Execution of Voluntary Movement
  • The Cerebellum
  • The Basal Ganglia
  • Box 22.1. Extracellular Recording of Motor Activity
  • Part 4. Development of the Nervous System
  • Chapter 23.. Development of the Nervous System
  • Early Neural Morphogenesis
  • Regional Specification of Neural Tissue
  • Determination of Neuronal and Glial Cell Identity
  • Axon Outgrowth
  • Axon Guidance
  • Target Innervation
  • Synapse Formation
  • Growth Factors and Survival of Neurons
  • Competitive Interactions during Development
  • General Considerations of Neural Specificity
  • Box 23.1. Discovery of Nerve Growth Factor
  • Chapter 24.. Denervation and Regeneration of Synaptic Connections
  • Changes in Axotomized Neurons and the Surrounding Glial Cells
  • Effects of Denervation on Postsynaptic Cells
  • Regeneration in the Vertebrate Peripheral Nervous System
  • Role of Basal Lamina at Regenerating Neuromuscular Synapses
  • Regeneration in the Mammalian CNS
  • Chapter 25.. Critical Periods in Visual and Auditory Systems
  • The Visual System in Newly Born Monkeys and Kittens
  • Effects of Abnormal Experience in Early Life
  • Requirements for Maintenance of Functioning Connections in the Visual System
  • Cellular and Molecular Mechanisms of Deprivation Changes
  • Critical Periods in the Auditory System
  • Critical Periods for Higher Functions
  • Part 5. Conclusion
  • Chapter 26.. Open Questions
  • Appendix A.. Current Flow in Electrical Circuits
  • Appendix B.. Metabolic Pathways for the Synthesis and Inactivation of Low-Molecular-Weight Transmitters
  • Appendix C.. Structures and Pathways of the Brain
  • Glossary
  • Bibliography
  • Index