Clinical pharmacology during pregnancy.

Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatme...

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Bibliographic Details
Edition:Second edition / edited by Donald Mattison, Lee-Ann Halbert.
Imprint:Amsterdam : Academic Press, 2021.
Description:1 online resource (1 volume) : illustrations.
Language:English
Subject:Obstetrical pharmacology.
Obstetrical pharmacology.
Electronic books.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/12660424
Hidden Bibliographic Details
Other authors / contributors:Mattison, Donald R., editor.
Halbert, Lee-Ann, editor.
ISBN:9780128189023
0128189029
Notes:Print version record.
Summary:Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.
Other form:Print version: Clinical pharmacology during pregnancy. Second edition. Amsterdam : Academic Press, 2021 9780128189023
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520 |a Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations. 
588 0 |a Print version record. 
505 0 |a Front Cover -- Clinical Pharmacology During Pregnancy -- Clinical Pharmacology During Pregnancy -- Copyright -- Dedication -- Contents -- Contributors -- Acknowledgment -- 1 -- Introduction -- References -- 2 -- Physiologic changes during pregnancy -- 2.1 Physiologic changes during pregnancy -- 2.2 Cardiovascular system -- 2.3 Respiratory system -- 2.4 Renal system -- 2.5 Gastrointestinal system -- 2.6 Hematologic and coagulation systems -- 2.7 Endocrine system -- 2.8 Summary -- References -- 3 -- Impact of pregnancy on maternal pharmacokinetics of medications -- 3.1 Introduction 
505 8 |a 3.2 Effects of pregnancy on pharmacokinetic parameters -- 3.2.1 Extraction ratio -- 3.2.2 Area under the concentration-time curve -- 3.2.3 Bioavailability -- 3.2.4 Clearance -- 3.2.5 Protein binding -- 3.2.6 Organ blood flow -- 3.2.7 Intrinsic clearance -- 3.2.8 Metabolism -- 3.2.8.1 CYP3A -- 3.2.8.2 CYP2D6 -- 3.2.8.3 CYP2C9 -- 3.2.8.4 CYP1A2 -- 3.2.8.5 CYP2C19 -- 3.2.8.6 CYP2B6 -- 3.2.8.7 CYP2E1 -- 3.2.8.8 Uridine diphosphate glucuronyltransferase -- 3.2.8.9 Alcohol dehydrogenase -- 3.2.8.10 Carbonyl reductase 1 -- 3.2.9 Renal -- 3.2.9.1 Filtration -- 3.2.9.2 Secretion/reabsorption 
505 8 |a 3.2.9.2.1 P-glycoprotein and organic anion transporter polypeptides -- 3.2.9.2.2 Organic anion transporter, oligopeptide transporters -- 3.2.9.2.3 Organic cation transporters, multidrug and extrusion transporters, and plasma monoamine transporter -- 3.2.9.2.4 pH-dependent changes in secretion and reabsorption -- 3.2.10 Volume of distribution -- 3.2.11 Half-life -- 3.3 Summary -- References -- 4 -- Medications and the breastfeeding mother -- 4.1 Medication use by the breastfeeding mother -- 4.2 Clinical pharmacology of drug transfer into breast milk -- 4.3 During delivery -- 4.4 General anesthesia 
505 8 |a 4.4.1 Volatile anesthetic agents -- 4.4.1.1 Halothane -- 4.4.1.2 Desflurane and sevoflurane -- 4.4.2 Intravenous anesthetic agents -- 4.4.2.1 Ketamine -- 4.4.2.2 Propofol -- 4.4.2.3 Etomidate -- 4.4.2.4 Thiopental -- 4.4.3 A general statement -- 4.5 Epidural anesthesia -- 4.6 Galactogogues including dietary supplements (including herbs) -- 4.7 Immediate postpartum period -- 4.8 Pain -- 4.8.1 Morphine -- 4.8.2 Codeine -- 4.8.3 Meperidine -- 4.8.4 Hydrocodone -- 4.9 Methadone -- 4.10 Resumption of prepregnancy medications -- 4.11 Psycho- and neurotropic drugs 
505 8 |a 4.11.1 Antidepressants, antipsychotics, anxiolytics, antiepileptics, and drugs for attention deficit hyperactivity disorder -- 4.12 Drugs not to give to the nursing mother postpartum -- 4.13 Oral contraceptives -- 4.13.1 Biologics and biopharmaceuticals (e.g., monoclonal antibodies) -- 4.13.2 Marijuana -- 4.14 Summary -- 4.15 Where to find information -- References -- 5 -- Fetal drug therapy -- 5.1 Introduction -- 5.2 Indications for fetal therapy -- 5.3 Strategies to achieve fetal drug therapy -- 5.3.1 Transplacental drug transfer -- 5.3.2 Direct fetal injection -- 5.3.3 Gene therapy 
650 0 |a Obstetrical pharmacology.  |0 http://id.loc.gov/authorities/subjects/sh85093763 
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655 0 |a Electronic books. 
655 4 |a Electronic books. 
700 1 |a Mattison, Donald R.,  |e editor. 
700 1 |a Halbert, Lee-Ann,  |e editor. 
776 0 8 |i Print version:  |t Clinical pharmacology during pregnancy.  |b Second edition.  |d Amsterdam : Academic Press, 2021  |z 9780128189023  |w (OCoLC)1263781507 
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