Palladium and nickel catalyzed transformations forming functionalized heterocycles /
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Author / Creator: | Yoon, Hyung. |
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Imprint: | Cham : Springer, 2020. |
Description: | 1 online resource (xxix, 212 pages) : illustrations (some color) |
Language: | English |
Series: | Springer Theses Springer theses. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/12607857 |
Summary: | This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility.Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions. |
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Physical Description: | 1 online resource (xxix, 212 pages) : illustrations (some color) |
Bibliography: | Includes bibliographical references. |
ISBN: | 9783030540777 3030540774 9783030540760 3030540766 |