Development of Neural Circuitry /

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Bibliographic Details
Imprint:Amsterdam ; London : Academic Press, 2009.
Description:1 online resource (ix, 230 pages 12 unnumbered pages of plates) : illustrations.
Series:Current topics in developmental biology ; v. 87.
Subject:Neural circuitry.
Neural networks (Neurobiology)
Neural circuitry.
Neural networks (Neurobiology)
Nerve Net -- growth & development.
Electronic books.
Electronic books.
Format: E-Resource Book
URL for this record:
Hidden Bibliographic Details
Other authors / contributors:Hobert, Oliver, editor.
Notes:Includes bibliographical references and index.
Text in English.
Print version record.
Summary:The nervous system is highly complex both in its structural order and in its ability to perform the many functions required for survival and interaction with the environment; understanding how it develops has proven to be one of the greatest challenges in biology. Such precision demands that key events at every developmental stage are executed properly and are coordinated to produce the circuitry underlying each of the adult nervous system's functions. This volume describes the latest research on the cellular and molecular mechanisms of neural circuitry development, while providing researchers with a one-stop overview and synthesis of contemporary thought in the area. Reviews current research findings on the development of neural circuitry, providing researchers an overview and synthesis of the latest contemporary thought in the cellular and molecular mechanisms that underlie the development of neural circuitry. Includes chapters discussing topics such as he guidance of nerve growth and the formation of plasticity of synapses, helping researchers better understand underlying mechanisms of neural circuit development and maintenance that may play a role in such human diseases/conditions as depression, anxiety, and pain. Chapters make use of a variety of human and animal models, allowing researchers to compare and contrast neural circuitry develoment across a wide spectrum of models.
Table of Contents:
  • Contributors
  • Preface
  • 1. Theoretical Models of Neural Circuit Development
  • 1. Introduction
  • 2. Theoretical Modeling in Axon Guidance
  • 3. Theoretical Modeling in the Retinotectal System
  • 4. Activity-Dependent Development
  • 5. Discussion
  • References
  • 2. Synapse Formation in Developing Neural Circuits
  • 1. Introduction
  • 2. Synaptogenesis During Development
  • 3. Building a Synapse
  • 4. Perspective
  • Acknowledgments
  • References
  • 3. The Developmental Integration of Cortical Interneurons into a Functional Network
  • 1. General Introduction
  • 2. The Classification of Cortical Interneuron Subtypes
  • 3. Development of Cortical Interneurons
  • 4. The Integration of Interneurons into Cortical Networks
  • Acknowledgments
  • References
  • 4. Transcriptional Networks in the Early Development of Sensory-Motor Circuits
  • 1. Introduction
  • 2. Intrinsic Programs Controlling Neuronal Fate Specification in the Ventral Spinal Cord
  • 3. Guidance and Synaptic Specificity of Motor Axons Projecting into the Limb
  • 4. Control of Sensory Neuron Specification and Connectivity
  • 5. Sensory-Motor Circuit Assembly and Function
  • 6. Conclusions
  • Acknowledgments
  • References
  • 5. Development of Neural Circuits in the Adult Hippocampus
  • 1. Development of Neural Circuits in the Adult Hippocampus
  • 2. Development of the Hippocampal Circuit
  • 3. Producing New Neurons from Adult Neural Stem Cells in the Hippocampus
  • 4. Maturation and Integration of Newly Generated Cells in the Hippocampal Circuitry
  • 5. Functional Implications of Neurogenesis in the Adult Hippocampus
  • 6. Concluding Remarks
  • References
  • 6. Looking Beyond Development: Maintaining Nervous System Architecture
  • 1. Introduction
  • 2. Maintenance of Cellular Features of Neurons
  • 3. Maintenance of the Architecture of Neuronal Ensembles
  • 4. Discussion
  • Acknowledgments
  • References
  • Index
  • Contents of Previous Volumes