Statistics applied to clinical trials /

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Bibliographic Details
Edition:4th ed.
Imprint:[Dordrecht] : Springer, c2009.
Description:1 online resource (xxi, 559 p.) : ill.
Format: E-Resource Book
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Other authors / contributors:Cleophas, Ton J. M.
Notes:Includes bibliographical references and index.
Description based on print version record.
Summary:Explains classical statistical analysis of clinical trials. This book addresses relatively novel issues, including equivalence testing, interim analysis, sequential analysis, meta-analysis, and provides a framework of the best statistical methods available for such purpose. It is suitable for investigators in the field of clinical trials.
Other form:Print version: Statistics applied to clinical trials. 4th ed. [Dordrecht] : Springer, c2009 9781402095221 1402095228
Summary:In clinical medicine appropriate statistics has become indispensable to evaluate treatment effects. Randomized controlled trials are currently the only trials that truly provide evidence-based medicine. Evidence based medicine has become crucial to optimal treatment of patients. We can define randomized controlled trials by using Christopher J. Bulpitt's definition "a carefully and ethically designed experiment which includes the provision of adequate and appropriate controls by a process of randomization, so that precisely framed questions can be answered". The answers given by randomized controlled trials constitute at present the way how patients should be clinically managed. In the setup of such randomized trial one of the most important issues is the statistical basis. The randomized trial will never work when the statistical grounds and analyses have not been clearly defined beforehand. All endpoints should be clearly defined in order to perform appropriate power calculations. Based on these power calculations the exact number of available patients can be calculated in order to have a sufficient quantity of individuals to have the predefined questions answered. Therefore, every clinical physician should be capable to understand the statistical basis of well performed clinical trials. It is therefore a great pleasure that Drs. T. J. Cleophas, A. H. Zwinderman, and T. F. Cleophas have published a book on statistical analysis of clinical trials. The book entitled "Statistics Applied to Clinical Trials" is clearly written and makes complex issues in statistical analysis transparant.
Physical Description:1 online resource (xxi, 559 p.) : ill.
Bibliography:Includes bibliographical references and index.