Cancer stem cell resistance to targeted therapy /
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Imprint: | Cham, Switzerland : Springer, [2019] |
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Description: | 1 online resource |
Language: | English |
Series: | Resistance to targeted anti-cancer therapeutics ; volume 19 Resistance to targeted anti-cancer therapeutics ; 19. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11913186 |
Other authors / contributors: | Maccalli, Cristina, editor. Todaro, Matilde, editor. Ferrone, Soldano, editor. |
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ISBN: | 9783030166243 3030166244 9783030166250 3030166252 9783030166267 3030166260 9783030166236 3030166236 |
Digital file characteristics: | text file PDF |
Notes: | Online resource; title from digital title page (viewed on July 18, 2019). |
Summary: | This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients. |
Other form: | Printed edition: 9783030166236 Printed edition: 9783030166250 Printed edition: 9783030166267 |
Standard no.: | 10.1007/978-3-030-16624-3 10.1007/978-3-030-16 |
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