Cancer stem cell resistance to targeted therapy /

This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistan...

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Bibliographic Details
Imprint:Cham, Switzerland : Springer, [2019]
Description:1 online resource
Language:English
Series:Resistance to targeted anti-cancer therapeutics ; volume 19
Resistance to targeted anti-cancer therapeutics ; 19.
Subject:Drug resistance in cancer cells.
Oncology.
Immunology.
Medicine.
Drug resistance in cancer cells.
Immunology.
Medicine.
Oncology.
Electronic books.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11913186
Hidden Bibliographic Details
Other authors / contributors:Maccalli, Cristina, editor.
Todaro, Matilde, editor.
Ferrone, Soldano, editor.
ISBN:9783030166243
3030166244
9783030166250
3030166252
9783030166267
3030166260
9783030166236
3030166236
Digital file characteristics:text file PDF
Notes:Online resource; title from digital title page (viewed on July 18, 2019).
Summary:This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
Other form:Printed edition: 9783030166236
Printed edition: 9783030166250
Printed edition: 9783030166267
Standard no.:10.1007/978-3-030-16624-3
10.1007/978-3-030-16