Contribution of Neuropeptide F (NPF) Neurons to Reward in Drosophila melanogaster /
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| Author / Creator: | Saver Cortes, Mathias Andres, author. |
|---|---|
| Imprint: | 2017. Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| Description: | 1 electronic resource (111 pages) |
| Language: | English |
| Format: | E-Resource Dissertations |
| Local Note: | School code: 0330 |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11715074 |
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| 100 | 1 | |a Saver Cortes, Mathias Andres, |e author. | |
| 245 | 1 | 0 | |a Contribution of Neuropeptide F (NPF) Neurons to Reward in Drosophila melanogaster / |c Mathias Andres Saver Cortes. |
| 260 | |c 2017. | ||
| 264 | 1 | |a Ann Arbor : |b ProQuest Dissertations & Theses, |c 2017 | |
| 300 | |a 1 electronic resource (111 pages) | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
| 337 | |a computer |b c |2 rdamedia |0 http://id.loc.gov/vocabulary/mediaTypes/c | ||
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| 500 | |a Advisors: Xiaoxi Zhuang; Ulrike Heberlein Committee members: Christian Hansel; Daniel Margoliash. | ||
| 502 | |b Ph.D. |c University of Chicago, Division of the Biological Sciences; Pritzker School of Medicine |d 2017. | ||
| 510 | 4 | |a Dissertation Abstracts International, |c Volume: 78-12(E), Section: B. | |
| 520 | |a In classical experiments performed by Olds & Milner in 1954, it was shown that rats learn to perform an operant lever-pressing behavior in order to receive an electric stimulus in specific brain nuclei, leading to the identification of what we currently know as mammalian "reward centers" and the discovery that neuronal activation in these brain regions is perceived as rewarding. For the fruit fly Drosophila melanogaster, it is known that specific subsets of neurons regulate different forms of reward. However, a more extensive circuit level description of the fly's reward circuit is missing. Here we present the development of a novel and high throughput 2-choice assay that employs optogenetic activation of neurons to study reward in Drosophila. This new system was characterized using activation of Neuropeptide F (NPF) neurons, a known rewarding stimulation. We showed that NPF neurons could be subdivided into different groups based upon their neuroanatomy and contribution to the NPF neuron activationinduced preference. Finally, we showed that this preference response is dependent on the activity of dopamine neurons. | ||
| 546 | |a English | ||
| 590 | |a School code: 0330 | ||
| 690 | |a Biology. | ||
| 710 | 2 | |a University of Chicago. |e degree granting institution. |0 http://id.loc.gov/authorities/names/n79058404 |1 http://viaf.org/viaf/143657677 | |
| 720 | 1 | |a Xiaoxi Zhuang |e degree supervisor. | |
| 720 | 1 | |a Ulrike Heberlein |e degree supervisor. | |
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