Investigating the hierarchy of subdivisions in primary motor cortex, and between primary motor and somatosensory cortices during naturalistic behaviors /
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Author / Creator: | Rajan, Alexander, author. |
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Imprint: | 2016. Ann Arbor : ProQuest Dissertations & Theses, 2016 |
Description: | 1 electronic resource (118 pages) |
Language: | English |
Format: | E-Resource Dissertations |
Local Note: | School code: 0330 |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11674585 |
Other authors / contributors: | University of Chicago. degree granting institution. |
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ISBN: | 9781339874166 |
Notes: | Advisors: Nicholas Hatsopoulos; David Freedman Committee members: Sliman Bensmaia; Lee Miller. This item is not available from ProQuest Dissertations & Theses. Dissertation Abstracts International, Volume: 77-12(E), Section: B. English |
Summary: | A popular framework to help comprehend the complicated connections and interactions between cortical areas is to place them in a so-called cortical hierarchy [1]. To do so is helpful not only to describe interactions between cortical areas and their neural processing, but also to make predictions. For example, one would expect a cortical area that is higher in the hierarchy to have more complex, or abstract, receptive or projection fields. Indeed, this functional difference in cortical areas is a defining characteristic of cortical hierarchies. Another defining characteristic are different patterns of laminar connections: ascending projections terminate on middle cortical layers, and descending projections terminate onto high and low cortical layers, avoiding the middle layers [2]. Thus, cortical hierarchies, in this dissertation, are defined by the functional properties of responses, and the neuroanatomical underpinnings of laminar connectivity. Here, I propose using spike-field coherence to measure the interactions between individual neurons in one cortical area and populations of neurons in another to validate the hierarchical structure between cortical areas. First I will show that these anatomically intertwined areas are synchronized in a low frequency band, and that this coherence is not symmetrical. I expect that rM1-cM1 spike-field coherence will precede cM1-rM1 spike-field coherence, and likewise that M1-S1 spike-field coherence will precede S1-M1 coherence. Additionally, I will provide support that coherence is a functional mechanism that is meaningful above and beyond either spikes or local fields. Finally, I will place these cortical areas in a somatomotor hierarchy, and discuss their evolutionary origins and roles in motor control. |
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