Investigating the hierarchy of subdivisions in primary motor cortex, and between primary motor and somatosensory cortices during naturalistic behaviors /

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Bibliographic Details
Author / Creator:Rajan, Alexander, author.
Ann Arbor : ProQuest Dissertations & Theses, 2016
Description:1 electronic resource (118 pages)
Format: E-Resource Dissertations
Local Note:School code: 0330
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Other authors / contributors:University of Chicago. degree granting institution.
Notes:Advisors: Nicholas Hatsopoulos; David Freedman Committee members: Sliman Bensmaia; Lee Miller.
This item is not available from ProQuest Dissertations & Theses.
Dissertation Abstracts International, Volume: 77-12(E), Section: B.
Summary:A popular framework to help comprehend the complicated connections and interactions between cortical areas is to place them in a so-called cortical hierarchy [1]. To do so is helpful not only to describe interactions between cortical areas and their neural processing, but also to make predictions. For example, one would expect a cortical area that is higher in the hierarchy to have more complex, or abstract, receptive or projection fields. Indeed, this functional difference in cortical areas is a defining characteristic of cortical hierarchies. Another defining characteristic are different patterns of laminar connections: ascending projections terminate on middle cortical layers, and descending projections terminate onto high and low cortical layers, avoiding the middle layers [2]. Thus, cortical hierarchies, in this dissertation, are defined by the functional properties of responses, and the neuroanatomical underpinnings of laminar connectivity. Here, I propose using spike-field coherence to measure the interactions between individual neurons in one cortical area and populations of neurons in another to validate the hierarchical structure between cortical areas. First I will show that these anatomically intertwined areas are synchronized in a low frequency band, and that this coherence is not symmetrical. I expect that rM1-cM1 spike-field coherence will precede cM1-rM1 spike-field coherence, and likewise that M1-S1 spike-field coherence will precede S1-M1 coherence. Additionally, I will provide support that coherence is a functional mechanism that is meaningful above and beyond either spikes or local fields. Finally, I will place these cortical areas in a somatomotor hierarchy, and discuss their evolutionary origins and roles in motor control.
Item Description:Advisors: Nicholas Hatsopoulos; David Freedman Committee members: Sliman Bensmaia; Lee Miller.
Physical Description:1 electronic resource (118 pages)
Access:This item is not available from ProQuest Dissertations & Theses.