Total synthesis of natural products with antimicrobial activity /

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Bibliographic Details
Author / Creator:	Giltrap, Andrew, author.
Imprint:	Singapore : Springer, 2018.
Description:	1 online resource (xxiv, 268 pages) : illustrations (some color)
Language:	English
Series:	Springer theses, 2190-5053 Springer theses,
Subject:	Natural products. Anti-infective agents. Pharmaceutical chemistry. Clinical biochemistry. Anti-infective agents. Clinical biochemistry. Natural products. Pharmaceutical chemistry.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11654615

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ISBN:	9789811088063 9811088063 9789811088056 9811088055
Digital file characteristics:	text file PDF
Summary:	This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Other form:	Print version: 9789811088056
Standard no.:	10.1007/978-981-10-8806-3 10.1007/978-981-10-8

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