Current strategies in cancer gene therapy /
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| Imprint: | Cham : Springer, 2017. |
|---|---|
| Description: | 1 online resource (124 pages) |
| Language: | English |
| Series: | Recent Results in Cancer Research ; v. 209 Recent results in cancer research ; 209. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11271055 |
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| 245 | 0 | 0 | |a Current strategies in cancer gene therapy / |c Wolfgang Walther, editor. |
| 260 | |a Cham : |b Springer, |c 2017. | ||
| 300 | |a 1 online resource (124 pages) | ||
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| 490 | 1 | |a Recent Results in Cancer Research ; |v v. 209 | |
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a 1 p53 Replacement Therapy for Cancer; Abstract; 1 Introduction; 2 p53-Mediated Cell Survival and Cell Death Signaling Pathways; 3 p53 Replacement Therapy; 3.1 Cationic Liposome Complex with a DNA Plasmid; 3.2 Replication-deficient Adenovirus Vector; 3.3 Replication-competent Adenovirus Vector; 3.4 Protein Transduction Therapy; 4 Bystander Effect of p53 Replacement Therapy; 5 Conclusion; Acknowledgments; References; 2 Retroviral Vectors for Cancer Gene Therapy; Abstract; 1 Introduction; 2 Anticancer Strategies Based on CARs and TCR; 2.1 T Cells; 2.2 T Precursor Cells; 2.3 NK Cells. | |
| 505 | 8 | |a 2.4 Induced Pluripotent Stem Cells (iPSC)3 Gene Therapy; 3.1 O-6-Methylguanine DNA Methyltransferase (MGMT); 3.2 Cytidine Deaminase and the Multidrug Resistance Gene 1 (MDR1); 3.3 Suicide Gene Strategies; 3.4 Genome Editing Strategies; 4 Conclusions; Acknowledgments; References; 3 Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells; Abstract; 1 Introduction; 1.1 MC DNA as Minimalistic Expression Cassette; 1.2 Non-viral Gene-Transfer Through Sleeping Beauty Transposition; 1.3 Principles of CAR Design; 1.4 Gene-Transfer Strategies and Clinical Experience with CAR T Cells. | |
| 505 | 8 | |a 2 Methodologies of SB-Minicircle and CAR T Cell Manufacturing2.1 Construction of Transposable MC Vectors; 2.2 Manufacturing of MC DNA; 2.3 Engineering of CAR T Cells; 2.4 Functional Testing of CAR T Cells; 3 Antitumor Function of Minicircle Engineered CAR T Cells; 3.1 Characterization of MC DNA; 3.2 Gene-Transfer Rate and Integration Profile; 3.3 Functional Characterization of CAR T Cells; 4 Future Perspectives; 4.1 GMP Minicircle Manufacturing; 4.2 Clinical Implementation; References; 4 Noncoding RNA for Cancer Gene Therapy; Abstract; 1 Introduction. | |
| 505 | 8 | |a 1.1 Mechanism and Function of Noncoding RNAs1.2 Design and Synthesis of Noncoding RNAs for Cancer Gene Therapy; 1.3 Delivery of Noncoding RNAs for Cancer Gene Therapy; 2 Conclusion; Acknowledgments; References; 5 mRNA Cancer Vaccines; Abstract; 1 mRNA Cancer Vaccines; 1.1 Introduction; 1.2 RNActive® Vaccines; 1.2.1 Induction of Antitumor Responses with RNActive® Vaccines; 1.2.2 Clinical Studies with RNActive® Vaccines; 1.2.3 Combination of RNActive® Vaccines with Chemotherapy or Radiation Therapy; 1.2.4 Clinical Study with RNActive® Vaccines in Combination with Radiotherapy. | |
| 505 | 8 | |a 1.2.5 Combination of RNActive® Vaccines with Immune Checkpoint Inhibitors1.3 Personalized mRNA Vaccines; 1.4 Cellular Vaccines: mRNA-Pulsed Dendritic Cells; 1.5 CAR T Cells; 2 Conclusion; Acknowledgments; References; 6 Gene Therapeutic Approaches to Overcome ABCB1-Mediated Drug Resistance; Abstract; 1 Introduction; 2 Resistance Overcoming Gene Therapy Approaches; 2.1 Delivery by Transfection; 2.2 Nanoparticle-Based Delivery; 2.3 Viral Delivery; 2.4 Bacterial Delivery; 2.5 Delivery by Jet-Injection; 3 Conclusion; 7 Bacterial Toxins for Oncoleaking Suicidal Cancer Gene Therapy; Abstract. | |
| 500 | |a 1 Introduction. | ||
| 504 | |a Includes bibliographical references. | ||
| 520 | |a This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications. | ||
| 650 | 0 | |a Cancer |x Gene therapy. |0 http://id.loc.gov/authorities/subjects/sh92005201 | |
| 650 | 7 | |a Oncology. |2 bicssc | |
| 650 | 7 | |a Medical genetics. |2 bicssc | |
| 650 | 7 | |a HEALTH & FITNESS |x Holism. |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS |x Reference. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Alternative Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Atlases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Essays. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Family & General Practice. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Holistic Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Osteopathy. |2 bisacsh | |
| 650 | 7 | |a Cancer |x Gene therapy. |2 fast |0 (OCoLC)fst00845367 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Walther, Wolfgang. | |
| 776 | 0 | 8 | |i Print version: |a Walther, Wolfgang. |t Current Strategies in Cancer Gene Therapy. |d Cham : Springer International Publishing, ©2017 |z 9783319429328 |
| 830 | 0 | |a Recent results in cancer research ; |v 209. |0 http://id.loc.gov/authorities/names/n42020830 | |
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