Hidden Bibliographic Details
| ISBN: | 9789811028991
9811028990
9789811028984
9811028982
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| Digital file characteristics: | text file PDF
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| Notes: | "Doctoral thesis accepted by Institute of Chemistry, Chinese Academy of Sciences, Beijing, China."
Includes bibliographical references.
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| Summary: | This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and?,?-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of?-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging?-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via?-addition. Highly enantiopure tetrahydropyridazinones and?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available?,?-unsaturated carboxylic acids were first successfully employed to generate the?,?-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α, β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α, β-unsaturated carboxylic acids were first successfully employed to generate the α, β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
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| Other form: | Print version: Chen, Xiangyu. New strategies for n-heterocyclic carbenes catalyzed annulations. Singapore : Springer, 2017 9811028982 9789811028984
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| Standard no.: | 10.1007/978-981-10-2899-1
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