Hidden Bibliographic Details
| Other authors / contributors: | Donnadieu, Emmanuel, editor.
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| ISBN: | 9783319422237
3319422235
9783319422220
3319422227
9783319825281
3319825283
9783319422213
3319422219
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| Digital file characteristics: | data file
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| Notes: | Includes bibliographical references and index.
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| Summary: | This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
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| Other form: | Print version: 9783319422213 3319422219
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| Standard no.: | 10.1007/978-3-319-42223-7
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