Optogenetics.
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| Author / Creator: | Hegemann, Peter. |
|---|---|
| Imprint: | Berlin : De Gruyter, 2013. |
| Description: | 1 online resource (240 pages) |
| Language: | English |
| Series: | Dahlem Workshop Reports Dahlem workshop reports. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11204879 |
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| 100 | 1 | |a Hegemann, Peter. | |
| 245 | 1 | 0 | |a Optogenetics. |
| 260 | |a Berlin : |b De Gruyter, |c 2013. | ||
| 300 | |a 1 online resource (240 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Dahlem Workshop Reports | |
| 505 | 0 | |a List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. | |
| 505 | 8 | |a 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. | |
| 505 | 8 | |a 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. | |
| 505 | 8 | |a 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. | |
| 505 | 8 | |a 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. | |
| 500 | |a 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons. | ||
| 520 | |a Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Neural transmission. |0 http://id.loc.gov/authorities/subjects/sh85091095 | |
| 650 | 0 | |a Neural networks (Neurobiology) |0 http://id.loc.gov/authorities/subjects/sh93002348 | |
| 650 | 0 | |a Electrooptical devices. |0 http://id.loc.gov/authorities/subjects/sh85042432 | |
| 650 | 0 | |a Physiological optics. |0 http://id.loc.gov/authorities/subjects/sh85095188 | |
| 650 | 7 | |a Biophysics. |2 bicssc | |
| 650 | 7 | |a Genetics (non-medical) |2 bicssc | |
| 650 | 7 | |a Human biology. |2 bicssc | |
| 650 | 7 | |a Neurosciences. |2 bicssc | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Zoology |x General. |2 bisacsh | |
| 650 | 7 | |a Electrooptical devices. |2 fast |0 (OCoLC)fst00907668 | |
| 650 | 7 | |a Neural networks (Neurobiology) |2 fast |0 (OCoLC)fst01036271 | |
| 650 | 7 | |a Neural transmission. |2 fast |0 (OCoLC)fst01036280 | |
| 650 | 7 | |a Physiological optics. |2 fast |0 (OCoLC)fst01063168 | |
| 650 | 7 | |a Nervennetz |2 gnd |0 http://d-nb.info/gnd/4041638-0 | |
| 650 | 7 | |a Optogenetik |2 gnd |0 http://d-nb.info/gnd/1043139133 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Sigrist, Stephan. | |
| 776 | 0 | 8 | |i Print version: |a Hegemann, Peter. |t Optogenetics. |d Berlin : De Gruyter, ©2013 |z 9783110270716 |
| 830 | 0 | |a Dahlem workshop reports. |0 http://id.loc.gov/authorities/names/n42030044 | |
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