RNA turnover in eukaryotes : nucleases, pathways and analysis of mRNA decay /

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Bibliographic Details
Imprint:San Diego, Calif. ; London : Academic, ©2008.
Description:1 online resource (xlviii, 607 pages, [5] pages of plates) : illustrations (some color).
Series:Methods in enzymology, 0076-6879 ; v. 448
Methods in enzymology ; v. 448.
Subject:Messenger RNA.
Genetic regulation.
Eukaryotic cells.
SCIENCE -- Life Sciences -- Molecular Biology.
Eukaryotic cells.
Genetic regulation.
Messenger RNA.
RNA, Messenger [MESH]
Eukaryotic Cells [MESH]
RNA Stability [MESH]
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11195245
Hidden Bibliographic Details
Other authors / contributors:Maquat, Lynne.
Kiledjian, Megerditch.
Notes:Includes bibliographical references and indexes.
Print version record.
Summary:Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. The control of biological processes, such as cellular growth and differentiation, is dependent on how the genetic material within a cell is expressed. The cellular physiology of mRNA-including mRNA processing, transport, localization, and turnover-is central to the process of gene expression. Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway. Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover which are central to the process of gene expression. Offers step-by-step lab instructions including necessary equipment and reagents.
Other form:Print version: RNA turnover in eukaryotes. San Diego, Calif. ; London : Academic, ©2008 9780123743787 0123743788