Peptidomimetics protocols /

In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety...

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Bibliographic Details
Imprint:Totowa, NJ : Humana Press, ©1999.
Description:1 online resource (xxx, 549 pages) : illustrations
Language:English
Series:Methods in molecular medicine ; 23
Methods in molecular medicine ; 23.
Subject:Peptides.
Amino acids -- Synthesis.
Heterocyclic chemistry.
Prodrugs.
Peptides -- chemistry.
Protein Conformation.
Amino acids -- Synthesis.
Heterocyclic chemistry.
Peptides.
Prodrugs.
Conformation des protéines.
Peptides.
Acides aminés.
Composés hétérocycliques.
Peptiden.
Synthese (chemie)
Wetenschappelijke technieken.
Chimie des composés hétérocycliques.
Peptides.
Acides aminés -- Synthèse.
Promédicaments.
Composés hétérocycliques.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11128917
Hidden Bibliographic Details
Other authors / contributors:Kazmierski, Wieslaw M.
ISBN:9781592596058
1592596053
9781617370595
0896035174
9780896035171
Notes:Includes bibliographical references and index.
Restrictions unspecified
Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010.
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212
English.
digitized 2010 HathiTrust Digital Library committed to preserve
Print version record.
Summary:In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of otherwise labile peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed. Peptidomimetics Protocols is the first book devoted to the practical synthetic preparation of peptide mimetics. Written by both academic and industrial synthetic organic and medicinal chemists, this book provides highly practical synthetic procedures for the generation of key peptide mimetics, and so immediately becomes a must-have desk reference and guide for all medicinal and pharmaceutical chemists engaged in the discovery and development of pharmaceuticals today
Other form:Print version: Peptidomimetics protocols. Totowa, NJ : Humana Press, ©1999 0896035174
Standard no.:10.1385/0896035174