Gene therapy of cancer : methods and protocols /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, ©2000.
Description:1 online resource (xvi, 645 pages) : illustrations
Series:Methods in molecular medicine ; 35
Methods in molecular medicine ; 35.
Subject:Cancer -- Gene therapy -- Laboratory manuals.
Neoplasms -- therapy.
Genetic Therapy -- methods.
Cancer -- Thérapie génique -- Manuels de laboratoire.
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Cancer -- Gene therapy.
Wetenschappelijke technieken.
Electronic books.
Handbooks and manuals.
Format: E-Resource Book
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Other authors / contributors:Walther, Wolfgang.
Stein, Ulrike.
Notes:Immunizing potential of cytokine-transduced tumor cells / M.P. Colombo and M. Rodolfo-Particle-mediated gene transfer into dendritic cells : A novel strategy for the induction of immune responses against tumor antigens / T. Tuting and A. Albers-Cancer gene therapy with heat shock protein-65 gene / K.V. Lukacs and A. Nakakes-Recombinant vaccinia virus mva for generation and analysis of t cell responses against tumor associated antigens / I. Drexler [and others]-Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy / J.E. Hecht and D.J. Waxman-Construction of p450-expressing tumor cell lines using retroviruses / J.E. Hecht, Y. Jounaidi and D.J. Waxman-7 in vitro methods for evaluation of p450-based anticancer gene therapy / D.H. JE and D.J. Waxman-8 tumor models for evaluation of p450 gene therapy in vivo / J.E. Hecht, P. Schreiber Schwartz and D.J. Waxman-9 intracellular single-chain antibodies for gene therapy / G. Bilbao [and others]-Combined adenoviral transfer of tumor suppressor and cell-cycle genes for tumor-cell apoptosis / K. Brand, V. Sandig and M. Strauss-Inhibition of cell growth by antisense oligonucleotides targeting the growth-related protein kinase c-raf / D. Fabbro [and others]-Igf-1 antisense strategies for cancer treatment / Y.X. Pan and D.D. Anthony-Anti-mdr1 ribozyme gene therapy / T. Ohnuma, H. Kobayashi and F.S. Wang-Anti-c-erb1b2 ribozyme for gene therapy of breast cancer / T. Suzuki, M. Bessho and K.J. Scanlon-Anti-k-ras1 ribozyme adenoviral vector for gene therapy of non-small cell lung cancer / Y.A. Zhang, J. Nemunaitis and A.W. Tong-Green fluorescent protein retroviral vector : Generation of high-titer producer cells and virus supernatant / W. Uckert, L. Pedersen and W. Gunzburg-Hsv-1 vectors for gene therapy of experimental cns tumors / U. Herrlinger [and others]-Intratumoral injection of naked DNA / J. Yang-Cationic liposome gene transfer / K. Kay Son-In vivo particle-mediated gene transfer for cancer therapy / A.L. Rakhmilevich and N.S. Yang-Gene targeting to hepatomas (afp) / S. Tsuruta, A. Ido and S. Nagataki-Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources / L. Chen-Chemotherapy-inducible vector for gene therapy of cancer / W. Walther [and others]-Oncolytic adenoviral vectors / R. Alemany and W.W. Zhang-Genetically modified clostridium for gene therapy of tumors / M.E. Fox [and others]-Tumor-targeted salmonella: Strain development and expression of the hsv-tk effector gene / D. Bermudes, B. Low and J.M. Pawelek-Ex vivo cytokine gene transfer in melanomas by using particle bombardment / D. Schadendorf-Intratumoral gene transfer of the hla-b7 gene into colon carcinoma metastases / E. Galanis and J. Rubin-Hybrid cell vaccination in patients with metastatic melanoma / U. Trefzer [and others]-Retroviral transfer of the herpes simplex virus-thymidine kinase (hsv-tk) gene for the treatment of cancer / R. Ramesh [and others]-Gene therapy for treatment of brain tumors (hsv-tkin vivo gene transfer) : A case study / F. Weber, F. Floeth and H. Bojar-Gene therapy of glioblastoma multiforme with a bicistronic retroviral vector expressing human il-2 and hsv-tk / G. Palu [and others]-Intratumoral gene transfer of the cytosine deaminase gene for the treatment of breast cancer / H.S. Pandha and N.R. Lemoine-Adenovirus-mediated wild-type p53 gene transfer into head and neck cancers / G.L. Clayman, D.K. Frank and P.A. Bruso-Direct DNA injection (p53) into hcc tumors / R.R. Mitry and N.A. Habib-A phase ii trial of intratumoral injection with a selectively replicating adenovirus (onyx-015) in patients with recurrent, refractory squamous cell carcinoma of the head and neck / D.H. Kirn-C-myb antisense oligonucleotide therapeutics for hematologic malignancies / S. Luger-Ovarian cancer gene therapy with brca1-an overview / P.S. Obermiller and J.T. Holt-Methods for chemoprotection and chemosensitization : Mdr-1 for chemoprotection using retroviruses to modify hematopoietic cells and cytosine deaminase for chemosensitization using adenoviral vectors to modify epithelian neoplastic cells / S. Shrimdkandada [and others].
Includes bibliographical references and index.
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Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010.
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
digitized 2010 HathiTrust Digital Library committed to preserve
Summary:In Gene Therapy of Cancer: Methods and Protocols, Wolfgang Walther and Ulrike Stein survey the rapidly evolving field cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer: Methods and Protocols offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, its readily reproducible, cutting-edge methods constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.
Other form:Print version: Gene therapy of cancer. Totowa, N.J. : Humana Press, ©2000 0896037142
Standard no.:10.1385/1592590861