Translational research methods for diabetes, obesity and cardiometabolic drug development : a focus on early phase clinical studies /dc Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors.

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Bibliographic Details
Imprint:London ; New York : Springer, [2015]
Description:1 online resource
Language:English
Subject:Diabetes Mellitus -- drug therapy.
Obesity -- drug therapy.
Clinical Trials, Phase I as Topic -- methods.
Clinical Trials, Phase II as Topic -- methods.
Translational Medical Research.
Drug development.
Diabetes -- Treatment.
Obesity -- Treatment.
MEDICAL / Pharmacology
Diabetes -- Treatment.
Drug development.
Obesity -- Treatment.
Diabetes.
Internal medicine.
Medicine.
Metabolic diseases.
Pharmaceutical technology.
Toxicology.
Electronic books.
Electronic books.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11090190
Hidden Bibliographic Details
Other authors / contributors:Krentz, Andrew J. editor.
Heinemann, Lutz editor
Hompesch, Marcus editor.
ISBN:9781447149200
1447149203
9781447149194
144714919X (print)
9781447149194 (print)
Notes:Includes bibliographical references and index.
Online resource; title from PDF title page (Ebsco, viewed Dec. 15, 2014).
Summary:This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Other form:Print version: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. Springer Verlag 2014 9781447149194
Standard no.:10.1007/978-1-4471-4920-0