Leveraging expression quantitative trait loci to elucidate the genetic architecture of type 2 diabetes /
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| Author / Creator: | Torres, Jason Matthew, author. |
|---|---|
| Imprint: | 2016. Ann Arbor : ProQuest Dissertations & Theses, 2016 |
| Description: | 1 electronic resource (173 pages) |
| Language: | English |
| Format: | E-Resource Dissertations |
| Local Note: | School code: 0330 |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/10862924 |
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| 100 | 1 | |a Torres, Jason Matthew, |e author. | |
| 245 | 1 | 0 | |a Leveraging expression quantitative trait loci to elucidate the genetic architecture of type 2 diabetes / |c Torres, Jason Matthew. |
| 260 | |c 2016. | ||
| 264 | 1 | |a Ann Arbor : |b ProQuest Dissertations & Theses, |c 2016 | |
| 300 | |a 1 electronic resource (173 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Advisors: Nancy J. Cox Committee members: Graeme Bell; Nancy J. Cox; Anna Di Rienzo; Louis Philipson. | ||
| 502 | |b Ph.D. |c University of Chicago, Division of the Biological Sciences, Committee on Molecular Metabolism and Nutrition |d 2016. | ||
| 506 | |a This item is not available from ProQuest Dissertations & Theses. | ||
| 510 | 4 | |a Dissertation Abstracts International, |c Volume: 77-10(E), Section: B. | |
| 520 | |a The enrichment of eQTLs mapped in insulin-responsive peripheral tissues among sets of T2D-associated variants suggests an important role for gene regulation in the genetic basis of T2D. In this body of work, I address outstanding questions about the overall contribution of regulatory variation to genetic susceptibility for T2D and the resolution of genes mapped as putative T2D genes. I employ heritability partitioning to determine the contribution of eQTLs mapped in human adipose tissue and skeletal muscle tissue to the proportion of T2D heritability attributable to common genetic variation. I then address the issue of gene mapping by predicting the genetic component of gene expression from eQTL data and sequentially test for association with T2D using a method that explicitly addresses the mechanism of transcription. | ||
| 546 | |a English | ||
| 590 | |a School code: 0330 | ||
| 690 | |a Genetics. | ||
| 690 | |a Medicine. | ||
| 710 | 2 | |a University of Chicago. |e degree granting institution. | |
| 720 | 1 | |a Nancy J. Cox |e degree supervisor. | |
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