Contribution of the host's microbiota to retroviral transmission and pathogenesis /

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Bibliographic Details
Author / Creator:Wilks, Jessica, author.
Ann Arbor : ProQuest Dissertations & Theses, 2015
Description:1 electronic resource (125 pages)
Format: E-Resource Dissertations
Local Note:School code: 0330
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Other authors / contributors:University of Chicago. degree granting institution.
Notes:Advisors: Tatyana Golovkina Committee members: Sasha Chervonsky; Sean Crosson; Howard Shuman.
This item is not available from ProQuest Dissertations & Theses.
Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Summary:My dissertation explores the contribution of commensal bacteria to retroviral transmission and pathogenesis. I have found that commensal bacteria do not contribute to the anti-retroviral humoral response. In addition, I have found that a enveloped retrovirus exploits the host membrane proteins, CD14, LBP, MD2, and TLR4 to bind commensal LPS and subvert the antiviral immune response. Finally, I have found that commensal bacteria are required for retrovirally-induced leukemia.